There’s a kind of paradox in pot-limit Omaha with regard to starting hand selection. On the one hand, since you are dealt four cards instead of two (as in Texas hold’em) and therefore are able to make lots of different hands when pairing your hole cards with the community cards, many more starting hands seem worth playing since any four-card combinations appears to have at least some potential to make a big hand.
On the other hand, the increased potential present in a four-card hand is precisely the reason why players should be even more circumspect about starting hand selection in pot-limit Omaha than they might be in no-limit hold’em. Let me try to explain.
Let’s say you are dealt a hand like Qc-Qd-5h-4h in a full-ring game of PLO. At first glance, this might seem to be a decent starting hand. After all you have a big pair, and the other two cards also provide straight and flush possibilities.
However, when you assess the potential of a starting hand in PLO, you need to take into account the fact that every player at the table has six potential two-card combinations to choose from when making a hand with three community cards.
Look at your hand. You have a pair of queens, which is good but actually will probably need a queen to flop (and no straights or flushes to be possible) in order to be competitive against table full of opponents’ hands. And you have the 5h and the 4h, which can make straights or flushes, sure, but the flush will be a small one and unless the A-2-3 comes out the straight won’t be the best possible straight, either.
Even worse, consider the other four two-card combinations here: Qc-5h, Qc-4h, Qd-5h, and Qd-4h. All are terrible starting hands in hold’em, meaning you are playing a PLO with very limited potential compared to an opponent holding, say, Jh-Th-Ts-9s, a hand with six good-to-excellent two-card combinations.
When choosing starting hands in PLO, you generally only want to play hands with four cards that are coordinated or “work together” well. In other words, avoid hands with “danglers” or cards that don’t work well with the others. Choose hands with good straight or flush possibilities, favoring those that can make you “nut” hands (or the best possible hands).
Also, when selecting starting hands be sure to take into account the special importance of position in PLO. You don’t want to be playing too many hands from early position, and when you do, you definitely want to be playing premium hands that can make the nuts, since it is so hard to control the size of the pot from up front in PLO.